![]() ![]() With the release of Windows 3.0 the following year, sales began to pick up and Microsoft soon became the market leader for word processors for IBM PC-compatible computers. The first version of Word for Windows was released in 1989. After its release, Word for Mac OS's sales were higher than its MS-DOS counterpart for at least four years. ![]() It fulfilled a need for a word processor that was more capable than MacWrite. Following the precedents of LisaWrite and MacWrite, Word for Mac OS added true WYSIWYG features. This was made easier by Word for DOS having been designed for use with high-resolution displays and laser printers, even though none were yet available to the general public. In 1985, Microsoft ported Word to the classic Mac OS (known as Macintosh System Software at the time). However, Microsoft steadily improved the product, releasing versions 2.0 through 5.0 over the next six years. It was not initially popular, since its user interface was different from the leading word processor at the time, WordStar. Advertisements depicted the Microsoft Mouse, and described Word as a WYSIWYG, windowed word processor with the ability to undo and display bold, italic, and underlined text, although it could not render fonts. Unlike most MS-DOS programs at the time, Microsoft Word was designed to be used with a mouse.
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![]() We provide a transgenic approach to inactivate maternal genes in zebrafish primary oocytes. As disrupting maternal gene functions is either time-consuming or technically challenging, early developmental programs regulated by maternal factors remain mostly elusive. Maternal products are exclusive factors to drive oogenesis and early embryonic development. Our findings suggest that maternal Nanog coordinates several gene regulatory networks that shape the embryo during gastrulation. Nanog is necessary for correct spatial expression of the ventral specifying genes bmp2b, vox, and vent, and neural transcription factor her3 It is also required for the correctly timed activation of endoderm genes and for the degradation of maternal eomesa mRNA via miR-430. We further demonstrate that the cell death in MZnanog embryos is cell-autonomous. We show that three independent defects in MZnanog mutants contribute to epiboly failure: yolk microtubule organization required for epiboly is abnormal, maternal mRNA fails to degrade due to the absence of miR-430 and actin structure of the yolk syncytial layer does not form properly. Without functional Nanog, epiboly is severely affected, embryo axes do not form and massive cell death starts at the end of gastrulation. ![]() In this study we characterize the development of maternal and zygotic MZnanog null mutant zebrafish embryos. Nanog has been implicated in establishment of pluripotency in mammals and in zygotic genome activation in zebrafish. We would like to show you a description here but the site won’t allow us. Be sure to visit my blog – Crazy 4 Webkinz – this week to get the scoop on the Black Friday sales as they’re announced by Ganz. After that, this beautiful golden bird will be gone forever! 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